Rapid acting drug delivery compositions

Details Rapid acting drug delivery compositions Rapid acting drug delivery compositions

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2558835

Drug formulations for systemic drug delivery with improved stability and rapid onset of action are described herein. The formulations may be administered via buccal administration, sublingual administration, pulmonary delivery, nasal administration, subcutaneous administration, rectal administration, vaginal administration, or ocular administration. In the preferred embodiments, the formulations are administered sublingually or via subcutaneous injection. The formulations contain an active agent and one or more excipients, selected to increase the rate of dissolution. In the preferred embodiment, the drug is insulin, and the excipients include a metal chelator such as EDTA and an acid such as citric acid.

La présente invention concerne des formulations de médicaments destinés à l'administration de médicaments systémiques à la statilité accrue et à déclenchement rapide de l'action. Ces formulations se prêtent aux administrations par voies buccale, sublinguale, pulmonaire, nasale, sous-cutanée, rectale, vaginale ou oculaire. Dans les modes de réalisation préférés, ces formulations s'administrent par voie sublinguale ou par injection sous-cutanée. Ces formulations contiennent un principe actif et un ou plusieurs excipients, sélectionnés pour augmenter la vitesse de dissolution. Dans le mode de réalisation préféré, le médicament est l'insuline, et les excipients incluent un chélateur de métal tel que l'ETDA (acide acide éthylènediaminetétracétique) et un acide tel que l'acide citrique.

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