Rapid and sensitive detection of aberrant protein...

Details Rapid and sensitive detection of aberrant protein... Rapid and sensitive detection of aberrant protein...

G - Physics

01

N

G01N 33/68 (2006.01)

Patent

CA 2361013

Methods, assays, and components are described in which biological samples can be rapidly and sensitively analyzed for the presence of species associated with neurodegenerative disease. Techniques and components are provided for diagnosis of disease, as well as for screening of candidate drugs for treatment of neurodegenerative disease. The techniques are simple, extremely sensitive, and utilize readily-available components. Binding species, capable of binding a neurodegenerative disease aggregate-forming or fibril-forming species, are fastened to surfaces of electrodes and surfaces of particles, or provided free in solution, to bind fibril-forming species and/or be involved in aggregation.

L'invention concerne des techniques, des analyses, et des composants dans lesquels des ~chantillons biologiques peuvent Útre rapidement et efficacement analys~s, afin de d~tecter la pr~sence d'esp­ces associ~es ~ des maladies neurod~g~n~ratives. Ces techniques et ces composants permettent de diagnostiquer une maladie et de cribler des m~dicaments candidats au traitement des maladies neurod~g~n~ratives. Les techniques sont simples, extrÚmement efficaces, et utilisent des composants rapidement disponibles. Des esp­ces de liaison, capables de se lier ~ des esp­ces formant des fibrilles ou des agr~gats associ~s ~ des maladies neurod~g~n~ratives, sont fix~es aux surfaces d'esp­ces formant des ~lectrodes et/ou sont impliqu~es dans une agr~gation.

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