Rapid production of autologous tumor vaccines by using hsv...

Details Rapid production of autologous tumor vaccines by using hsv... Rapid production of autologous tumor vaccines by using hsv...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2287156

An autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes simplex virus amplicon containing the gene for an immunomodulatory protein to provide transient expression of the immunomodulatory protein by the cells. The tumor cells may be transduced with the herpes simplex amplicons ex vivo or in vivo. Suitable immunomodulatory proteins include cytokines, for example, interleukins, interferons, and chemokines such as RANTES; intercellular adhesion molecules, for example ICAM- 1 and costimulatory factors such as B7.1. The tumor cells may also be transduced with one or more species of amplicon containing genes for two or more different immunomodulatory proteins.

On produit un vaccin autologue contre des cellules tumorales en transduisant les cellules tumorales avec un amplicon du virus de l'herpès simplex renfermant le gène pour permettre à une protéine immunomodulatrice d'assurer l'expression transitoire de la protéine immunomodulatrice par les cellules. Il se peut que les cellules tumorales transduisent avec les amplicons d'herpès simplex ex vivo ou in vivo. On peut citer, à titre de protéines immunomodulatrices adaptées, les cytokines, les interleukines, les interférons et les chémokines telles que RANTES; les molécules d'adhésion intercellulaire, par exemple ICAM-1, et les facteurs co-stimulateurs tels que B7.1. Les cellules tumorales peuvent également être transduites avec une ou plusieurs espèces de gènes contenant des amplicons pour au moins deux protéines immunomodulatrices différentes.

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