Rapid purification by polymer supported quench

C - Chemistry – Metallurgy – 08 – F

Patent

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Details

C08F 8/00 (2006.01) C07B 61/00 (2006.01) C07B 63/04 (2006.01) C07C 231/02 (2006.01) C07C 231/24 (2006.01) C07C 233/65 (2006.01) C07C 273/18 (2006.01) C07C 303/38 (2006.01) C07C 311/16 (2006.01) C07D 211/86 (2006.01) C07D 231/12 (2006.01) C07D 249/12 (2006.01) C07D 295/215 (2006.01) C07D 317/60 (2006.01) C07F 9/22 (2006.01) C07F 9/44 (2006.01) C08G 81/00 (2006.01) C08G 85/00 (2006.01)

Patent

CA 2251700

Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one ore more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

Nouveaux réactifs de refroidissement brusque supportés par des polymères, de formule P-L-Q dans laquelle P est un polymère à faible réactivité chimique, soluble ou insoluble, Q est un ou plusieurs réactifs de refroidissement brusque, ou des sels d'addition basiques ou acides desdits réactifs, qui sont capables de réaction covalente sélective avec des sous-produits non désirés ou un excédent de réactifs et L est un ou plusieurs agents de liaison chimiquement robustes joignant P à Q. Des procédés de préparation desdits réactifs, des procédés d'utilisation desdits réactifs dans la purification rapide d'intermédiaires et de produits de synthèse dans la synthèse organique, la chimie combinatoire et la synthèse organique automatisée sont également décrits.

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