Rapidly cleavable substrate for hiv protease

Details Rapidly cleavable substrate for hiv protease Rapidly cleavable substrate for hiv protease

C - Chemistry, Metallurgy

07

K

530/7.06, 167/10

C07K 7/06 (2006.01) C07K 14/16 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2005516

- 1 - Abstract of the disclosure A rapidly cleavable substrate for HIV protease Hepta- to nona-peptides of the formula A - B - C - D - E - Opr - F - G - H, in which A is absent or represents Val, Ile or Thr, B denotes Ser, Thr or Phe, D denotes Asp or Ala, E denotes Tyr or Phe, Opr denotes 5-oxaproline, F denotes Ile, Leu, Val, Thr or Gln, G denotes Val, Ile, Ser or Arg, and H is absent or represents Gln, Glu, Pro or Thr, as well as the salts thereof are used for locating and detecting HIV protease and for testing possible inhibitors of HIV protease. They are prepared by known methods of peptide chemistry, preferably by means of solid-phase synthesis.

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