Rapidly decomposing chitosan-based pellets

C - Chemistry – Metallurgy – 08 – J

Patent

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Details

C08J 3/12 (2006.01) A61J 3/00 (2006.01) A61K 9/16 (2006.01) B01J 2/06 (2006.01) C08J 9/28 (2006.01) C08L 5/08 (2006.01)

Patent

CA 2382902

The invention relates to porous, rapidly disintegrating, active substance-containing pellets based on chitosan or a basic chitosan derivative, manufactured according to a dripping method wherein an aqueous solution or dispersion of chitosan or a basic chitosan derivative, one or more active substances, possibly further active substances and an acid is dripped into a cooling liquid having a temperature of maximally -5°C, thereby causing solidification of the solution or dispersion in the form of droplets, and wherein the solidified droplets or pellets are isolated and dried. The invention further relates to the use of these pellets in the manufacture of medicaments or diagnostic agents.

La présente invention concerne des pastilles renfermant un principe actif, à décomposition rapide, poreuses et fabriquées à base de chitosane ou d'un dérivé de chitosane basique, selon un procédé goutte-à-goutte. Dans ledit procédé, une solution ou une dispersion aqueuse, constituée de chitosane ou d'un dérivé de chitosane basique, d'un ou plusieurs principes actifs, éventuellement d'autres agents auxiliaires et d'un acide, est introduite goutte-à-goutte dans un liquide de refroidissement, à une température d'au plus 5 DEG C, ce qui conduit à une solidification sous forme de gouttelettes, puis les gouttelettes ou pastilles solidifiées sont isolées et séchées. Cette invention concerne également l'utilisation des pastilles dans la production d'un médicament ou d'un agent de diagnostic.

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