Rapidly disintegrating lyophilized oral formulations of a...

Details Rapidly disintegrating lyophilized oral formulations of a... Rapidly disintegrating lyophilized oral formulations of a...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/19 (2006.01) A61K 31/4402 (2006.01) A61K 31/5377 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2664290

Disclosed is a lyophilized rapidly disintegrating solid dosage form, one embodiment of which comprises a thrombin receptor antagonist such as, formula (A), or a pharmaceutically acceptable salt or hydrate thereof, a polymer such as gelatin, and a matrix forming agent such as mannitol. Systems for effectively buffering the pre-lyophilized suspension are taught, along with methods of treating patients at risk for acute coronary syndrome by administering such a rapidly disintegrating solid dosage form.

La présente invention concerne une forme pharmaceutique solide à délitement rapide, dont un mode de réalisation comporte un antagoniste du récepteur de la thrombine de formule (A), ou un sel ou hydrate pharmaceutiquement acceptable de celui-ci, un polymère tel que de la gélatine, et un agent formant matrice, tel que le mannitol. L'invention concerne également des systèmes de tamponnage efficace de la suspension préalablement lyophilisée, ainsi que des procédés de traitement de patients à risque du syndrome coronaire aigu par l'administration d'une telle forme pharmaceutique solide à délitement rapide.

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