A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 31/415 (2006.01) A61K 31/635 (2006.01)
Patent
CA 2419592
A molded article such as a tablet is provided for administration to an oral cavity of a subject to treat or prevent a cyclooxygenase-2 mediated condition, disorder or disease. The molded article comprises a moldable blend of a therapeutically effective amount of a selective cyclooxygenase-2 inhibitory drug with a pharmaceutically acceptable excipient carrier system consisting predominantly of one or more carbohydrates, wherein ingredients and amounts thereof in the molded article and a process for preparing the molded article are selected such that the molded article exhibits rapid disintegration in the oral cavity, and wherein the moldable blend is prepared by a process step not requiring wet granulation.
Cette invention concerne un article moulé, tel qu'un comprimé, à administration par voie orale pour le traitement ou la prévention d'états, de troubles ou de maladies induits par la cyclooxygénase-2. Cet article moulé comprend un mélange d'une dose thérapeutiquement efficace d'un médicament inhibiteur sélectif de la cyclooxygénase-2 et d'un système d'excipient acceptable au plan pharmaceutique, composé majoritairement d'un ou de plusieurs hydrates de carbone. Les ingrédients et les doses utilisés pour l'article moulé et le procédé de fabrication dudit article sont choisis de telle sorte que ledit article se désintègre rapidement dans la cavité buccale, la fabrication ne faisant par ailleurs pas intervenir de procédé de granulation par voie humide.
Kararli Tugrul T.
Kontny Mark J.
Le Trang T.
Osler Hoskin & Harcourt Llp
Pharmacia Corporation
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