Rapidly disintegrating solid oral dosage form

Details Rapidly disintegrating solid oral dosage form Rapidly disintegrating solid oral dosage form

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/51 (2006.01)

Patent

CA 2408848

Disclosed is a rapidly disintegrating solid oral dosage form of a poorly soluble active ingredient and at least one pharmaceutically acceptable water- soluble or water dispersible excipient, wherein the poorly soluble active ingredient particles have an average diameter, prior to inclusion in the dosage form, of less than about 2000 nm. The dosage form of the invention has the advantage of combining rapid presentation and rapid dissolution of the active ingredient in the oral cavity.

L'invention concerne une forme galénique orale solide à désintégration rapide d'un principe actif faiblement soluble et d'au moins un excipient hydrosoluble ou hydrodispersible pharmaceutiquement acceptable. Les particules du principe actif faiblement soluble présentent un diamètre, avant leur intégration en forme galénique, inférieur à environ 2000 nm. La forme galénique de l'invention présente l'avantage de combiner une présentation rapide et une dissolution rapide du principe actif dans la cavité orale.

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