Rar(gamma)-specific retinobenzoic acid derivatives

Details Rar(gamma)-specific retinobenzoic acid derivatives Rar(gamma)-specific retinobenzoic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 235/38 (2006.01) A61K 31/195 (2006.01) A61K 31/196 (2006.01) A61K 31/235 (2006.01) A61K 31/245 (2006.01) A61K 31/365 (2006.01) A61K 31/44 (2006.01) A61K 31/695 (2006.01) C07D 213/30 (2006.01) C07D 307/88 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2175854

Retinoid-like activity is exhibited by compounds of the formula Image wherein X is F, Cl, OH or CH3, Y is H or F, R1-R6 are each independently hydrogen or C1-C6 alkyl, n is an integer of 1 to 4 and R7 is hydrogen or a carboxyl-protecting group, and pharmaceutically acceptable salts thereof. The compounds of formula I selectively interact with the retinoic acid subtype RAR.gamma. and have been found to lack the liver toxicity associated with systemic administration of non-selective retinoids.

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