Ras-binding protein (pre1)

Details Ras-binding protein (pre1) Ras-binding protein (pre1)

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 38/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/32 (2006.01) C07K 17/00 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12P 21/06 (2006.01) C12P 21/08 (2006.01) G01N 33/18 (2006.01)

Patent

CA 2304209

Disclosed is a Ras-binding protein designated PRE1. PRE1 occurs naturally in various mammalian tissues and cell types. An isolated DNA endocing PRE1, vectors and cells containing the DNA, and PRE1-specific antibodies are also disclosed. Also disclosed is an in vitro screening method for indentifying a substance which modulates PRE1-Ras binding, and an in vitro method for identifying a substance that modulates PRE1 gene expression.

L'invention concerne une protéine fixatrice de Ras désignée par PRE1. PRE1 se trouve naturellement dans différents tissus et types cellulaires de mammifères. L'invention concerne également l'ADN isolé codant PRE1, des vecteurs et des cellules contenant cet ADN, et des anticorps spécifiques de PRE1. L'invention concerne en outre un procédé de criblage in vitro servant à identifier une substance qui module la liaison PRE1-Ras, et une technique in vitro d'identification d'une substance qui module l'expression du gène PRE1.

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