Ras oncogen p21 peptide vaccines

Details Ras oncogen p21 peptide vaccines Ras oncogen p21 peptide vaccines

A - Human Necessities

61

K

A61K 39/00 (2006.01) C07K 14/82 (2006.01)

Patent

CA 2372187

The invention relates to synthetic peptide mixtures which elicit T cellular immunity, for use in cancer vaccines and compositions for anti-cancer treatment. Preferred peptides are RAS p21 (5-21, 49-73 and 52-70) mutant peptides and in particular the mutants G12A, G12C, G12D, G12R, G12S, G12V, G13D, Q61H, Q61K, Q61L and Q61R.

L'invention concerne des mélanges de peptides synthétiques qui élicitent l'immunité cellulaire T, à utiliser dans des vaccins contre le cancer, ainsi que des compositions conçues pour des traitements anticancéreux. Les peptides préférés sont des peptides mutants p21 RAS (5-21, 49-73 et 52-70) et, en particulier, les mutants G12A, G12C, G12R, G12S, G12V, G13D, Q61H, Q61K, Q61L et Q61R.

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