A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/135 (2006.01)
Patent
CA 2588293
This invention provides a solid pharmaceutical composition comprising rasagiline or a pharmaceutically acceptable salt of rasagiline, and particles having a non-filamentous microstructure of at least two sugar alcohols. This invention also provides a solid pharmaceutical composition comprising rasagiline or a pharmaceutically acceptable salt of rasagiline, a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols, a supplemental sugar alcohol, a supplemental flow agent, and a supplemental disintegrant. This invention further provides a method of treating a subject afflicted with Parkinson~s disease comprising administering to the subject a therapeutically effective amount of the solid pharmaceutical composition, thereby treating the subject. Finally, this invention provides a process of making such solid pharmaceutical compositions.
L'invention concerne une composition pharmaceutique solide comprenant de la rasagiline ou un sel pharmaceutiquement acceptable de rasagiline, et des particules ayant une structure non filamenteuse d'au moins deux alcools de sucre. L'invention concerne également une composition pharmaceutique solide comprenant de la rasagiline ou un sel pharmaceutiquement acceptable de rasagiline, un mélange d'un délitant, d'un agent d'écoulement et de particules ayant une structure non filamenteuse d'au moins deux alcools de sucre, un alcool de sucre supplémentaire, un agent d'écoulement supplémentaire et un délitant supplémentaire. L'invention concerne en outre un procédé de traitement d'un sujet souffrant de la maladie de Parkinson, procédé consistant à administrer au sujet, une quantité thérapeutiquement efficace de la composition thérapeutique solide, et à traiter ainsi le sujet. L'invention concerne enfin un procédé de fabrication de telles compositions pharmaceutiques solides.
Gilbert Adrian
Licht Daniella
Patashnik Shulamit
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
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