Rat grf and analogs

Details Rat grf and analogs Rat grf and analogs

C - Chemistry, Metallurgy

07

K

530/7.1, 530/7.2

C07K 14/60 (2006.01) A23K 1/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1247601

RAT GRF AND ANALOGS ABSTRACT OF THE DISCLOSURE Rat hypothalamic GRF (GH releasing factor) has been synthesized and has the formula: H-His-Ala-Asp- Ala-Ile-Phe-Thr-Ser-Ser-Tyr-Arg-Arg-Ile-Leu-Gly-Gln-Leu- Tyr-Ala-Arg-Lys-Leu-Leu-His-Glu-Ile-Met-Asn-Arg-Gln-Gln- Gly-Glu-Arg-Asn-Gln-Glu-Gln-Arg-Ser-Arg-Phe-Asn-OH. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in animals and which have the formula: Image is a natural amino acid or des-R44; and Y signifies the carboxyl moiety of the amino acid residue at the C-terminus and is the radical -COOR,-CRO,-CONHNHR, -CON(R)(R') or -CH2OR, with R and R' being lower alkyl, fluoro lower alkyl or hydrogen. These peptides or biologically active fragments thereof may be administered to animals, including humans, to stimulate the release of GH and may be used diagnostically.

450244

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