Rat model of diabetic nephropathy

Details Rat model of diabetic nephropathy Rat model of diabetic nephropathy

A - Human Necessities

01

K

A01K 67/02 (2006.01) A61K 49/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2533315

A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound~s effect of diabetic nephropathy is disclosed. In one embodiment, this method comprises the steps of (a) exposing the test compound to the rat of claim 1, wherein the rat would develop progressive proteinuria and glomerulosclerosis leading to diabetic nephropathy in the absence of the test compound, and (b) comparing the rat~s development of diabetic nephropathy with a control T2DN mimic rat that has not been exposed to the test compound.

L'invention porte sur un modèle de rat de néphropathie diabétique. Dans un autre mode de réalisation, l'invention porte sur un procédé d'évaluation des effets d'un composé test de néphropathie diabétique. Dans un mode de réalisation différent, ce procédé consiste (a) à exposer le composé test au rat mentionné à la revendication 1, le rat développant une protéinurie et une glomérolosclérose progressives entraînant la néphropathie diabétique en l'absence du composé test, et (b) à comparer le développement chez le rat de la néphropathie diabétique avec un rat mimétique T2DN de contrôle qui n'a pas été exposé au composé test.

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