Rate control during af using cellular intervention to...

Details Rate control during af using cellular intervention to... Rate control during af using cellular intervention to...

A - Human Necessities

61

N

A61N 1/362 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61N 1/05 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2605592

A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient- specific needs.

L'invention concerne une méthode et un dispositif d'intervention biologique qui produisent une modification persistante d'un noeud AV qui est physiologiquement stable une fois que l'agent est parvenu à maturation, mais peut être modifié par application subséquente d'un agent. En particulier, l'agent générique est utilisé pour moduler un noeud dans un système de conduction cardiaque comprenant une régulation du rythme faisant appel à un ou à une combinaison d'une famille de canaux K+ ou équivalents. En particulier, le canal est utilisé pour ralentir la conduction en générant en courant sortant pendant l'optimisation des phases du potentiel d'actions et de la repolarisation, réduisant ainsi le courant disponible pour exciter les cellules situées en aval. Le canal biologique utilisé peut-être par exemple un canal Kv 1,3. Cette méthode permet d'inverser la modulation ou la régulation de différents rythmes cardiaques (BPM)

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