Rational evolution of cytokines for higher stability, the...

Details Rational evolution of cytokines for higher stability, the... Rational evolution of cytokines for higher stability, the...

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 14/475 (2006.01) C07K 14/505 (2006.01) C07K 14/52 (2006.01) C07K 14/53 (2006.01) C07K 14/535 (2006.01) C07K 14/54 (2006.01) C07K 14/555 (2006.01) C07K 14/575 (2006.01) C07K 14/61 (2006.01) C12N 15/20 (2006.01) C12N 15/24 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2498319

Processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided is a rational method for generating protein variants and the resulting variants.

La présente invention concerne des traitements et des systèmes visant à une évolution dirigée à haut rendement des peptides et protéines, plus particulièrement de cytokines intervenant dans des constructions biologiques complexes. L'invention concerne également, d'une part un procédé rationnel permettant de générer des variantes de protéines, et d'autre part les variantes ainsi obtenues.

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