Rationally designed antibodies

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/505 (2006.01) C07K 14/52 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2436671

Antibodies or fragments thereof having CDR regions replaced or fused with biologically active peptides are described. Flanking sequences may optionally be attached at one or both the carboxy-terminal and amino-terminal ends of the peptide in covalent association with adjacent framework regions. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities.

L'invention concerne des anticorps ou des fragments d'anticorps présentant des régions de détermination complémentaires (CDR) remplacées par ou fusionnées avec des peptides biologiquement actifs. Des régions flanquantes peuvent éventuellement être fixées à une ou aux deux extrémités carboxy-terminales et amino-terminales du peptide en association covalente avec des régions structurelles adjacentes. Les compositions contenant de tels anticorps ou fragments d'anticorps sont utiles dans des modalités thérapeutiques et diagnostiques.

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