Rationally designed antibodies

Details Rationally designed antibodies Rationally designed antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/22 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 7/00 (2006.01) A61P 39/00 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/16 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2507494

Antibodies or fragments thereof having at least two CDR regions replaced or fused with biologically active peptides are described. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities.

L'invention concerne des anticorps ou des fragments de ceux-ci comprenant au moins deux régions CDR (régions de détermination de la complémentarité) remplacées par des peptides actifs sur le plan biologique ou fusionnées avec ceux-ci. L'invention concerne également des compositions renfermant de tels anticorps ou fragments de ceux-ci, lesquelles sont utiles dans des modalités thérapeutiques et diagnostiques.

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