Rationally designed heparinases derived from heparinase i...

Details Rationally designed heparinases derived from heparinase i... Rationally designed heparinases derived from heparinase i...

C - Chemistry, Metallurgy

12

N

C12N 15/60 (2006.01) A61K 38/51 (2006.01) C12N 9/88 (2006.01) C12N 9/99 (2006.01) C12N 11/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2341412

Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.

L'invention concerne des héparinases modifiées qui présentent une spécificité de liaison et une activité modifiées. L'invention concerne en outre des acides nucléiques isolés codant ces héparinases ainsi que des vecteurs et des cellules hôtes. L'invention concerne également des procédés relatifs à l'utilisation des héparinases modifiées.

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