Rationally-designed meganucleases with altered sequence...

Details Rationally-designed meganucleases with altered sequence... Rationally-designed meganucleases with altered sequence...

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2626262

Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.

L'invention concerne des méganucléases LAGLIDADG conçues rationnellement et des procédés de préparation desdites méganucléases. L'invention concerne également des procédés d'utilisation des méganucléases pour générer des cellules et des organismes recombinés ayant une séquence ADN introduite dans un nombre limité de loci à l'intérieur du génome, ainsi que des procédés de thérapie génique destinés au traitement d'infections pathogènes et à des applications in vitro dans les domaines du diagnostic et de la recherche.

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