C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/08 (2006.01) C07K 16/00 (2006.01) C12N 15/13 (2006.01) C40B 40/02 (2006.01) C40B 50/06 (2006.01)
Patent
CA 2697193
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
L'invention concerne la résolution les lacunes inhérentes aux procédés connus de génération de bibliothèques de polynucléotides codant des anticorps en concevant spécifiquement des bibliothèques avec longueurs et séquences déterminées. Les bibliothèques sont conçues pour refléter le répertoire pré-immunitaire naturellement créé par le système immunitaire de l'homme et reposent sur la conception rationnelle renseignée après examen de bases de données publiques des séquences d'anticorps humains.
Feldhaus Michael
Gerngross Tillman U.
Vasquez Maximiliano
Wittrup K. Dane
Adimab Inc.
Riches Mckenzie & Herbert Llp
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