Rbm3 protein in colorectal cancer prognostics

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2749392

The present invention provides means, such as a method, for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second group, wherein the prognosis of subjects of the first group is better than the prog-nosis of subjects of the second group. The method comprises the steps of: evaluating an amount of RBM3 protein in at least part of a sample earlier obtained from the subject and determining a sample value corresponding to the evaluated amount; comparing said sample value with a predetermined reference value; and if said sample value is higher than said reference value, concluding that the subject belongs to the first group; and if said sample value is lower than or equal to said reference value, concluding that the subject belongs to the second group.

La présente invention a pour objet des moyens, tels qu'un procédé, permettant de déterminer si un sujet mammalien souffrant d'un cancer colorectal appartient à un premier ou à un second groupe, le pronostic des sujets du premier groupe étant meilleur que le pronostic des sujets du second groupe. Le procédé comprend les étapes consistant à : évaluer la quantité de protéine RBM3 dans au moins une partie d'un échantillon obtenu auparavant du sujet et déterminer la valeur d'un échantillon correspondant à la quantité évaluée ; comparer ladite valeur de l'échantillon avec une valeur de référence prédéterminée ; et si ladite valeur de l'échantillon est supérieure à ladite valeur de référence, conclure que le sujet appartient au premier groupe et si ladite valeur de l'échantillon est inférieure ou égale à ladite valeur de référence, conclure que le sujet appartient au second groupe.

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