A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2538619
The present invention provides a method for designing a re-targeted toxin conjugate for use in treating a medical condition or disease. Also provided, is the use of said conjugates in the manufacture of a medicament for treating medical conditions or diseases. The conjugates include a Targeting Moiety, which directs the conjugate to a desired target cell, and are characterised by a Targeting Moiety that increases exocytic fusion in the target cell. The present invention also provides methods for identifying agonists suitable for use as Targeting Moieties, and methods for preparing conjugates comprising said Targeting Moieties, to re-target a toxin to a cell of therapeutic interest. In particular, the present invention describes a method for designing a toxin conjugate, and describes therapeutic applications of said conjugates to inhibit or reduce cellular processes. Even more particularly, the present invention describes a method for designing toxin conjugates based upon non- cytotoxic toxins able to inhibit exocytosis, such as clostridial neurotoxins, and describes therapeutic applications of said conjugates to inhibit or reduce exocytosis (for example secretion, or the delivery of proteins such as receptors, transporters, and membrane channels to the plasma membrane of a cell).
L'invention concerne un procédé pour élaborer un conjugué de toxines reciblé destiné à être utilisé en traitement d'un état pathologique ou d'une maladie. L'invention concerne également l'utilisation de conjugués de ce type pour produire un médicament destiné à traiter des états pathologiques ou des maladies. Ces conjugués comprennent une fraction de ciblage qui dirige le conjugué vers une cellule cible voulue et ils sont caractérisés par une fraction de ciblage qui augmente la fusion exocytique dans la cellule cible. L'invention concerne enfin des procédés permettant d'identifier des agonistes pouvant être utilisés comme fractions de ciblage, ainsi que des procédés de préparation de conjugués comprenant lesdites fractions de ciblage.
Chaddock John
Foster Keith
Penn Charles
Fasken Martineau Dumoulin Llp
Health Protection Agency
Syntaxin Limited
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