Reaction monitoring of chiral molecules using fourier...

G - Physics – 01 – N

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G01N 21/19 (2006.01) G01J 4/00 (2006.01) G01N 1/20 (2006.01) G01N 21/05 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2542758

A method and apparatus to monitor the enantiomeric excess of chiral molecules participating in a chemical reaction. The method includes real time monitoring of the chemical reaction by obtaining a VCD spectra and an IR spectra of the chemical compounds in the reaction, and manipulating the spectra to obtain a % EE value. Using such real time information, the reaction parameters can be changed to shift the reaction to produce more of one chiral molecule than another.

L'invention concerne un procédé et un appareil permettant de surveiller l'excédent énantiomère de molécules chirales participant à une réaction chimique. Ce procédé comprend la surveillance en temps réel de la réaction chimique qui consiste à obtenir un spectre de dichroïsme circulaire vibratoire et un spectre infrarouge des composés chimiques impliqués dans la réaction et la manipulation desdits spectres afin d'obtenir un pourcentage d'excédent énantiomère. Grâce à ces informations obtenues en temps réel, les paramètres de réaction peuvent être modifiés afin de changer la réaction pour produire plus de molécules chirales qu'une autre réaction.

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