C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/24 (2006.01) C07D 317/08 (2006.01) C07D 317/22 (2006.01) C07D 317/28 (2006.01) C07F 9/14 (2006.01) C07F 9/655 (2006.01) C07H 19/00 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2402822
The invention relates to the production of modified oligonucleotides and to their use for conjugation reactions. The invention further relates to reagents and to methods for producing aldehyde-modified oligonucleotides that contain aldehydes that are protected (masked) as acetals. Once said acetals are incorporated into the oligonucleotides the oligonucleotides are converted to aldehydes and are used for conjugation. The conjugation reaction can be carried out with the free oligonucleotide or with the oligonucleotide that is still immobilized on the substrate.
L'invention concerne la production d'oligonucléotides modifiés et leur utilisation pour des réactions de conjugaison. Elle concerne également des réactifs et des procédés pour produire des oligonucléotides modifiés par de l'aldéhyde, lesdits oligonucléotides contenant comme acétals des aldéhydes protégés (masqués). Après incorporation des acétals dans les oligonucléotides, ces derniers sont convertis en aldéhydes et utilisés pour la réaction de conjugaison. Cette réaction peut s'effectuer avec l'oligonucléotide libre ou avec l'oligonucléotide encore lié au substrat.
Fetherstonhaugh & Co.
Nanogen Recognomics Gmbh
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