Reactive oxygen generating enzyme inhibitor with nitric...

Details Reactive oxygen generating enzyme inhibitor with nitric... Reactive oxygen generating enzyme inhibitor with nitric...

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2562177

A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury, atherosclerosis, sickle cell disease, diabetes, Alzheimer's disease, Parkinson's disease, ALS and asthma and to obtain proper contraction of heart, skeletal and smooth muscle.

L'invention concerne un inhibiteur d'enzyme de génération d'oxygène réactif à bioactivité de donneur NO, par exemple de l'allopurinol nitré, utilisé dans le traitement de l'insuffisance cardiaque, de l'angor stable, d'un trouble ischémique, d'une lésion ischémique consécutive à la perfusion, de l'athérosclérose, de la dépranocytose, du diabète, de la maladie d'Alzheimer, de la maladie de Parkinson, de la SLA, et de l'asthme, ainsi que pour obtenir une contraction adaptée du coeur, des muscles squelettiques et des muscles lisses.

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