Reactive polymers and copolymers, method of their...

Details Reactive polymers and copolymers, method of their... Reactive polymers and copolymers, method of their...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 47/32 (2006.01) A61K 48/00 (2006.01) C08F 120/56 (2006.01) C08F 128/06 (2006.01) C08F 220/56 (2006.01) C08F 228/06 (2006.01)

Patent

CA 2533199

The solution concerns reactive polymers and copolymers based on N- (2~hydroxypropyl)methacrylamide, which contain reactive thiazolidine-2-thione groups in side chains of the polymers or at the ends of polymer chains. The solution also includes a method of their preparation and their use for synthesis of polymer drugs and conjugates with proteins and preparation of gene delivery systems.

L'invention se rapporte à des polymères et des copolymères réactifs à base de <I>N</I>-(2-hydroxypropyl)methacrylamide contenant des groupes thiazolidine-2-thione réactifs dans des chaînes latérales des polymères ou aux extrémités des chaînes de polymères. Leur procédé de préparation est également décrit, ainsi que leur utilisation dans la synthèse de médicaments et de conjugués polymères contenant des protéines et dans la préparation de systèmes de transport de gènes.

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