Reactive vesicle and functional substance-fixed vesicle

Details Reactive vesicle and functional substance-fixed vesicle Reactive vesicle and functional substance-fixed vesicle

A - Human Necessities

61

K

A61K 47/24 (2006.01) A61K 9/127 (2006.01) A61K 39/385 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) C07F 9/6506 (2006.01) C08G 65/332 (2006.01) C08G 65/335 (2006.01)

Patent

CA 2137297

A reactive vesicle comprising, as a vesicle-forming component, a reactive phospholipid derivative represented by the following general formula (1) and a functional substance-fixed vesicle prepared by reacting the reactive vesicle with a functional substance: Image in which R1 C(=O) and R2 C(=O) each represent an aliphatic acyl group, R3 denotes a hydrogen atom or a methyl group, OA represents oxyalkylene groups of 2 - 4 carbon atoms, n indicates the average number of moles of added oxyalkylene groups and is 1 - 1,000, p is 0 or 1, X represents Image with q and r being each an integer of 0 to 4 or 1 to 4, respectively, and M denotes a hydrogen atom or an alkali metal atom. The vesicle facilitates effective attachment of various functional substances by way of a covalent bond to the ends of (poly)oxyalkylene chains, and has superior long term storage stability.

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