Reagent and method for determining activity of retroviral...

Details Reagent and method for determining activity of retroviral... Reagent and method for determining activity of retroviral...

C - Chemistry, Metallurgy

12

Q

150/3.2, 150/15.

C12Q 1/37 (2006.01) C07K 14/16 (2006.01) C12Q 1/70 (2006.01) G01N 21/76 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2033254

Novel fluorogenic substrates for retroviral protease, e.g. HIV protease, having the chemical structure X-Thr-Ile-Nle-Phe(Y)-Gln-Arg-NH2 wherein X is a fluorogenic group and Y is an acceptor for the fluorogenic group, and their use in a fluorometric method for the determination of retroviral protease is disclosed.

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