Reagent and method for inhibition of n-ras expression

Details Reagent and method for inhibition of n-ras expression Reagent and method for inhibition of n-ras expression

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A61K 31/70 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2205075

The invention relates to enzymatic RNA molecules which cleave mutant N-ras mRNA, preferably at a NUX cleavage site (N = any base, X = A, C or U), having preferably the sequences 5'-CCAACACCUGAUGAGCGUUAGCGAAACCUGCU-3' or 5'-UCCCAACCUGAUGAGCGUUAGCGAAACACCUG-3', modified derivatives thereof, pharmaceuticals containing such molecules and use of such molecules for the preparation of pharmaceuticals for the treatment of diseases involving abnormal cell growth and/or differentiation.

La présente invention a trait à des molécules d'ARN enzymatique qui coupent les ARNm N-ras mutants, de préférence à un site de coupure NUX (N = une base quelconque, X = A, C ou U), ayant de préférence les séquences 5'-CCAACACCUGAUGAGCGUUAGCGAAACCUGCU-3' ou 5'-UCCCAACCUGAUGAGCGUUAGCGAAACACCUG-3', dérivés modifiés de ces molécules, produits pharmaceutiques contenant ces molécules et usage de ces molécules dans la préparation de produits pharmaceutiques pour le traitement de maladies caractérisées par une croissance ou une différenciation cellulaire anormale.

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