Reagent and process for quantitatively measuring antibodies

Details Reagent and process for quantitatively measuring antibodies Reagent and process for quantitatively measuring antibodies

A - Human Necessities

61

K

167/139, 167/37

A61K 39/395 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1243944

Abstract Antibodies against bacterial peptidoglycans Antibodies from the classes of immunoglobulins A, M and E against the peptide sub-unit pentapeptide L-Ala-D-Glu(L-Lys-D-Ala-D-Ala) of peptidoglycan in biological test material and against bacterial cell walls containing these peptidoglycans may be extracted from human plasma and are useful in the investigation of bacterial infections. Such antibodies may be characterized by their ability to bind to: a) pentapeptides of formula I R - A1 -D -Ala (I) (wherein R represents an amino acid component with 1 - 3 amino acid residues selected from the group comprising Gly, L-Ala, D-Glu, L-Lys; and A1 represents one of the amino acid residues D-Ala, D-Ser, D-Val or D-Leu); and/or b) bacterial cell walls or cell wall material containing pentapeptides of general formula I; and/or c) Gram-positive bacteria containing pentapeptides of formula I.

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