Reagent enabling the antigen characteristic of hepatitis b...

Details Reagent enabling the antigen characteristic of hepatitis b... Reagent enabling the antigen characteristic of hepatitis b...

G - Physics

01

N

402/109, 167/44

G01N 33/546 (2006.01) C08F 216/34 (2006.01) G01N 33/543 (2006.01) G01N 33/576 (2006.01)

Patent

CA 1228446

PATENT Reagent enabling the antigen characteristic of hepatitis B virus to be determined with very high sensitivity in human biological liquids. An invention of: Jean DUHEILLE Bernard PAU Pierre GROS Société Anonyme called: SANOFI ABSTRACT The present invention relates to polyfunctional hydrophilic spherical microparticles of uniform size which contain from 5 to 95% of units originating from the co- polymerization of an aldehyde of the formula CH2 = Image R1 being an alkyl radical, from 5 to 90% of units origi- nating from the copolymerization of an acrylic acid ester of the formula Image , in which R2 is H or alkyl and R3 is a hydroxyalkyl group, less than 15% of units originating from an acrylic acid derivative chosen from amongst Image and Image R4, R5 and R6 being alkyl radicals, and from 0.1 to - 2 - 10% of units originating from a cross linking product. The invention also relates to a process for the preparation of the said microparticles and to the use of these microparticles for the nephelometric determination of HBs antigen.

433801

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