Reagent for detecting and monitoring viral infections

Details Reagent for detecting and monitoring viral infections Reagent for detecting and monitoring viral infections

G - Physics

01

N

G01N 33/569 (2006.01) C07K 14/05 (2006.01) G01N 33/536 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2295962

The invention concerns a reagent for diagnosing an infection caused by a virus, characterised in that it comprises essentially a mixture consisting of (1) an immunodominant fragment of a protein of said virus comprising not more than 60 aminoacids, preferably between 20 and 30 aminoacids and (2) a mixture (called mixotope) of convergent combining peptides, derived from said immunodominant fragment, which peptides are obtained by total or partial artificial degeneration of said immunodominant fragment by systematic or partial replacement of each aminoacid by another according to an appropriate substitution matrix. The invention concerns a reagent for detecting and monitoring infections caused by the Epstein-Barr virus or EBV, which is, in particular, the causal agent of infectious mononucleose and its applications for detecting an EBV infection at any stage of the infection (primo-infection, healthy carriers and induced tumours). Said diagnosis reagent comprises essentially a mixture consisting of (1) a C-terminal fragment of the protein VCAp18 SEQ ID n· 1 of the Epstein-Barr virus (EBV) comprising not more than 60 aminoacids, preferably between 20 and 30 aminoacids, and (2) a mixture or mixotope of convergent combining peptides, derived from said C-terminal fragment.

Réactif de diagnostic d'une infection provoquée par un virus, caractérisé en ce qu'il comprend essentiellement un mélange constitué par (1) un fragment immunodominant d'une protéine dudit virus comprenant au plus 60 acides aminés, de préférence entre 20 et 30 acides aminés et (2) un mélange (dénommémixotope) de peptides combinatoires convergents, dérivés dudit fragment immunodominant, lesquels peptides sont obtenus par dégénération artificielle complète ou partielle dudit fragment immunodominant par remplacement systématique ou partiel de chaque amino acide par un autre selon une matrice de remplaçabilité convenable. Réactif de détection et de suivi des infections provoquées par le virus d'Epstein-Barr ou EBV, qui est, notamment, l'agent causatif de la mononucléose infectieuse et ses applications pour la détection, d'une infection à EBV, à n'importe quel stade de l'infection (primo-infection, porteurs sains et tumeurs induites). Ledit réactif de diagostic comprend essentiellement un mélange constitué par (1) un fragment C-terminal de la protéine VCAp18 SEQ ID n~ 1 du virus d'Epstein-Barr (EBV) comprenant au plus 60 acides aminés, de préférence entre 20 et 30 acides aminés, et (2) un mélange ou mixotope de peptides combinatoires convergents, dérives dudit fragment C-terminal.

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