Reagent for singlet oxygen determination

C - Chemistry – Metallurgy – 07 – D

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C07D 311/82 (2006.01) C07D 493/08 (2006.01) C07D 493/10 (2006.01) C07D 493/22 (2006.01) G01N 21/78 (2006.01) G01N 31/22 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2326561

Compounds represented by general formula (I) or salts thereof, wherein R1, R2, R3, R4, R5, and R6 each independently represents hydrogen, halogeno, C1-6 alkyl, or C1-6 alkoxyl; R7 and R8 each independently represents C1-6 alkyl or optionally substituted aryl; R9 and R10 each independently represents hydrogen, C1-6 alkyl, or C1-6 alkoxyl; and R11 represents hydrogen or C1-12 alkanoyl. The compounds are substantially nonfluorescent and react with singlet oxygen under physiological conditions to give a fluorescent substance. They are hence useful as a reagent for singlet oxygen determination.

L'invention concerne des composés représentés par la formule générale (I) suivante ou leurs sels. Dans la formule selon l'invention, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ et R?6¿ représentent chacun indépendamment un hydrogène, un halogène, un alkyle en C¿1-6? ou un alcoxyle en C¿1-6?; R?7¿ et R?8¿ représentent chacun indépendamment un alkyle en C¿1-6? ou un aryle éventuellement substitué; R?9¿ et R?10¿ représentent chacun indépendamment un hydrogène, un alkyle en C¿1-6? ou un alcoxyle en C¿1-6?; et R?11¿ représente un hydrogène, ou un alcanoyle en C¿1-12?. Les composés sont sensiblement non fluorescents et réagissent avec un oxygène singulet dans des conditions physiologiques pour donner une substance fluorescente. Ils sont donc utiles comme réactifs de détermination d'oxygène singulet.

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