Reagent for the detection of fibrinolytic activity

Details Reagent for the detection of fibrinolytic activity Reagent for the detection of fibrinolytic activity

A - Human Necessities

61

K

A61K 49/00 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2065147

2065147 9102546 PCTABS00003 A diagnostic reagent for the detection in vivo of increased release of a fibrinolytic enzyme or increased fibrinolytic activity in the human or animal body comprises an antibody reactive with a fibrinolytic enzyme, or a fragment of the antibody, labelled with a substance which permits the detection in vivo of binding of the antibody to the fibrinolytic enzyme. In one embodiment, increased clearance of the antibody is provided by subsequent administration of the fibrinolytic enzyme with which the antibody is reactive. The fibrinolytic enzyme is preferably t-PA.

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