Reagents and methods for cancer treatment and prevention

Details Reagents and methods for cancer treatment and prevention Reagents and methods for cancer treatment and prevention

A - Human Necessities

61

K

A61K 39/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2647542

The invention generally relates to the prevention and/or treatment of cancer, and, more specifically, to the treatment of tumors, including solid tumors and their metastases, without radiation or standard chemotherapeutic agents. In one embodiment, the invention involves a method comprising: a) providing a subject with tumor cells, b) removing at least a portion of said tumor cells from said subject to create removed cells, c) treating at least a portion of said removed cells ex vivo, using stimulating agents, including thapsigargin and/or thapsigargin-related compounds, so as to create treated tumor cells; and d) introducing said treated tumor cells (or fragments thereof) in vivo into the same subject to generate anticancer therapeutic effects.

De manière générale, l'invention concerne la prévention et/ou le traitement du cancer, et, plus spécifiquement, le traitement de tumeurs, y compris des tumeurs solides et leurs métastases, sans le recours à un rayonnement ou à des agents chimiothérapeutiques classiques. Dans un mode de réalisation, l'invention concerne un procédé consistant à : a) administrer à un sujet des cellules tumorales, b) prélever au moins une partie desdites cellules tumorales dudit sujet afin de générer des cellules prélevées, c) traiter au moins une partie desdites cellules prélevées ex vivo à l'aide d'agents de stimulation, incluant la thapsigargine et/ou des composés de type thapsigargine, afin de générer des cellules tumorales traitées ; et d) introduire lesdites cellules tumorales traitées (ou des fragments de ces cellules) in vivo dans le même sujet pour générer des effets thérapeutiques anticancéreux.

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