Reagents and methods for detecting a polymorphic protein

Details Reagents and methods for detecting a polymorphic protein Reagents and methods for detecting a polymorphic protein

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2727790

The present invention provides antibodies that differentially react with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein, proteins, cells, viral particles, compositions, and kits comprising same. The invention also provides methods for determining a haptoglobin type of a subject and methods for testing a subject for susceptibility to diabetic complications.

La présente invention concerne des anticorps qui réagissent de manière différentielle avec les variants alléliques dune protéine polymorphe, des procédés didentification de ceux-ci, un fragment de liaison dantigène compris dans ceux-ci, des protéines, des cellules, des particules virales, des compositions, et des kits comprenant ceux-ci. Linvention concerne en outre des procédés pour déterminer un type dhaptoglobine dun sujet et des procédés pour tester un sujet pour la sensibilité à des complications diabétiques.

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