Reagents and methods for detecting influenza virus proteins

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) A61K 39/145 (2006.01) A61K 39/385 (2006.01) C07K 14/11 (2006.01) C07K 16/10 (2006.01) G01N 33/15 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2717221

Antibodies that specifically bind to a peptide having an amino acid sequence as found at the N-terminus of the HA2 fusion peptide of the influenza A virus may be raised by inoculating a mammal with a conjugate of the peptide. In one embodiment, the conjugate comprises the peptide linked to a spacer (e.g. 6- aminocaproic acid) and a carrier protein (e.g. KLH). The antibodies may be used as a universal reagent for detecting HA proteins of influenza viruses. The antibodies are useful as versatile reagents for laboratory research and vaccine potency determination, especially in the event of pandemic influenza outbreaks.

L'invention porte sur des anticorps qui se lient spécifiquement à un peptide ayant une séquence d'acides aminés telle que trouvée à l'extrémité N-terminale du peptide de fusion HA2 du virus de la grippe A, qui peuvent être développés par inoculation d'un mammifère avec un conjugué du peptide. Dans un mode de réalisation, le conjugué comprend le peptide lié à un groupe d'intercalation (par exemple, l'acide 6-aminocaproïque) et une protéine porteuse (par exemple KLH). Les anticorps peuvent être utilisés en tant que réactif universel pour détecter les protéines HA des virus de la grippe. Les anticorps sont utiles en tant que réactifs polyvalents pour la recherche en laboratoire et la détermination de la puissance d'un vaccin, notamment dans le cas de poussées de grippe pandémiques.

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