Reagents and methods for identification of binding agents

Details Reagents and methods for identification of binding agents Reagents and methods for identification of binding agents

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2415919

A method for identifying a desired binding agent that interferes with the interaction between a protein, protein fragment, polypeptide or a peptide and a binding surrogate. The method comprises combining the protein, protein fragment, polypeptide or peptide, the binding surrogate and a binding agent. Detecting a decrease inthe interaction between the protein, protein fragment, polypeptide or peptide from the binding surrogate indicates that the binding agent interferes with the interaction. Proteins useful in the method include the tau protein phosphorylated at threonine (231), the Amyloid Precursor Protein (APP) phosphorylated at threonine (668 and cdc25 phosphorylated at threonine (48). Compounds identified by the method are useful in the treatment of Alzheimers' disease and cancer.

L'invention concerne un procédé permettant d'identifier un liant désiré intervenant dans la réaction entre une protéine, un fragment de protéine, un polypeptide ou un peptide et un substitut de liaison. Le procédé consiste à combiner la protéine, le fragment de protéine, le polypeptide ou le peptide, le substitut de liaison et un liant. La détection d'une diminution d'une réaction entre la protéine, le fragment de protéine, le polypeptide ou le peptide et le substitut de liaison indique que le liant intervient dans ladite réaction. Les protéines utilisées dans le procédé décrit dans cette invention comprend la protéine tau phosphorylée à la thréonine 231, la protéine précurseur amyloïde (APP) phosphorylée à la thréonine 668 et la cdc25 phosphorylée à la thréonine 48. Les composés identifiés au moyen de ce procédé sont utilisés pour le traitement de la maladie d'Alzheimer et du cancer.

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