Reagents and methods for identification of vaccines

Details Reagents and methods for identification of vaccines Reagents and methods for identification of vaccines

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 9/64 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2103788

2103788 9213560 PCTABS00014 Cells, serum or fractions thereof from exposed hosts, especially those with demonstrated ability to protect against infection are screening reagents to identify antigens for use in protective vaccines. Biological materials from exposed native hosts can be validated in vivo in an irrelevant host by their ability to destroy or impair the infectious agent. Validation is performed by implanting the infectious agent in a membrane enclosure into an animal host to which the candidate screening reagent has been transferred. The candidate providing sucessful destruction or impairment of the infectious agent can then be used to screen antigens produced by cDNA expression libraries or in extracts of the infectious agents to identify components of effective vaccines. Using this method, candidate heartworm immunogens, in particular one of 39 kd, have been identified.

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