C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/24 (2006.01) C07C 213/00 (2006.01) C07C 231/02 (2006.01) C07C 235/80 (2006.01) C07F 9/09 (2006.01)
Patent
CA 2708148
This invention relates to the synthesis for a precursor of E6020, compound 26, via a .beta.-keto amide alcohol intermediate, compound 22, The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation. The .beta.-keto amide alcohol intermediate compound 22 is a compound of formula (3). Compound
L'invention concerne la synthèse d'un précurseur de E6020, composé 26, via un intermédiaire ß-céto amide alcool, composé 22. La synthèse comprend la réaction du composé 22 avec le composé 25 et l'intermédiaire résultant est oxydé pour produire le composé 26, le précurseur de E6020. Les composés 22 et 25 et leurs formes cristallines représentent des modes de réalisation séparés de l'invention. L'invention concerne également des composés de formules (3) et (4) et leurs procédés de préparation. L'intermédiaire ß-céto amide alcool, composé 22 est un composé de formule (3). Le composé 25 est un composé de formule (4).
Decosta Bruce
Fang Francis G.
Foy James E.
Hawkins Lynn
Lemelin Charles
Eisai R&d Management Co. Ltd.
Gowling Lafleur Henderson Llp
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