Reagents and methods for the detection and quantification of...

C - Chemistry – Metallurgy – 07 – K

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C07K 16/44 (2006.01) A61K 39/395 (2006.01) C07D 493/10 (2006.01) C07F 9/6561 (2006.01) C07K 14/00 (2006.01) C07K 16/18 (2006.01) C12N 5/18 (2006.01) C12N 9/00 (2006.01) G01N 33/531 (2006.01) G01N 33/532 (2006.01) G01N 33/533 (2006.01) G01N 33/542 (2006.01) G01N 33/58 (2006.01) G01N 33/78 (2006.01)

Patent

CA 2131727

2131727 9320442 PCTABS00027 Immunoassay methods and reagents for the specific quantification of thyroxine in a test sample are disclosed employing antibodies prepared with thyroxine derivatives of formula (2) wherein P is an immunogenic carrier material and X is a linking moiety. The present invention also describes the synthesis of unique labelled reagent of formula (4) wherein Q is a detectable moiety and W is a linking moiety, preferably fluorescein or a fluorescein derivative.

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