C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) C07K 16/44 (2006.01) G01N 33/533 (2006.01) G01N 33/577 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2178590
A murine monoclonal IgG antibody is provided which is useful in the detection of methotrexate in body fluids. This monoclonal antibody, designated 4-351-178, may be employed in an assay for methotrexate, preferably a fluorescence polarization immunoassay (FPIA) of urine. Monoclonal antibody 4-351-178 is characterized by having no detectable cross-reactivity with 7-hydroxymethotrexate. Also disclosed is a hybridoma cell line, ATCC HB 11467, which produces the monoclonal antibody of the invention.
L'invention concerne un anticorps monoclonal murin IgG utilisé dans la détection du méthotrexate dans les liquides biologiques. Cet anticorps monoclonal désigné par 4-354-178 peut être utilisé dans une technique de détection du méthotrexate, de préférence un dosage immunologique à polarisation de fluorescence (FPIA) de l'urine. L'anticorps monoclonal 4-351-178 se caractérise par l'absence de réactivité croisée détectable avec le 7-hydroxyméthotrexate. L'invention porte également sur une lignée cellulaire d'hybridome, ATC HB 11467, produisant l'anticorps monoclonal selon l'invention.
Juveland Sherri L.
Tyner Joan D.
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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