Reagents and methods for the quantification of imipramine or...

Details Reagents and methods for the quantification of imipramine or... Reagents and methods for the quantification of imipramine or...

C - Chemistry, Metallurgy

12

N

C12N 9/96 (2006.01) A61K 39/395 (2006.01) C07D 223/28 (2006.01) C07D 405/12 (2006.01) C07K 16/44 (2006.01) G01N 33/53 (2006.01) G01N 33/533 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2110916

Immunoassay methods and reagents for the specific quantification of imipramine or desipramine in a test sample are dis- closed. The measurement of imipramine or desipramine is accomplished in a specific immunoassay employing antibodies pre- pared with imipramine or desipramine derivatives of formula (III), wherein P is an immunogenic carrier material, X is two heter- oatoms, Y is a linking group comprising from 1 to 6 carbon atoms and P is an immunogenic carrier material, and wherein for imipramine, R is CH3, and for desipramine, R is H. The present invention also describes the synthesis of unique labeled rea- gents of the structure of formula (IV), wherein Z is a linking group comprising 1 to 4 carbon atoms and 0 to 2 heteroatoms and Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and wherein for imipramine, R1 is CH3, and for desipramine, R1 is H.

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