Reagents and methods for the quantification of total...

Details Reagents and methods for the quantification of total... Reagents and methods for the quantification of total...

C - Chemistry, Metallurgy

07

K

C07K 16/44 (2006.01) A61K 39/395 (2006.01) C07D 313/12 (2006.01) C07K 14/00 (2006.01) C09B 57/00 (2006.01) G01N 33/531 (2006.01) G01N 33/533 (2006.01) G01N 33/542 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2111467

Immunoassay methods and reagents for the quantification of total doxepins (i.e., E-doxepin, Z-doxepin, E-desmethyldox- epin, and Z-desmethyldoxepin) in a test sample are disclosed. The quantification of total doxepins is accomplished in an immu- noassay employing antibodies and labeled reagents prepared with doxepin derivatives of formula (II), wherein Y-Z can be C=CH or N-CH2, R1 is a linking group, R2 can be H or CH3 and Q can be a detectable moiety or an immunogenic carrier material. The antibody reagent comprises antibodies which are capable of binding to total doxepins and which are produced with one or more immunogens prepared from the doxepin derivative of formula (II), and the labeled reagent is also pre- pared from the doxepin derivative of formula (II).

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