Reagents and methods for using human embryonic stem cells to...

Details Reagents and methods for using human embryonic stem cells to... Reagents and methods for using human embryonic stem cells to...

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2648218

The invention provides biomarker profiles of cellular metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human embryonic stem cells (hESC) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds.

L'invention concerne des profils de biomarqueurs associés à des métabolites cellulaires et des méthodes de criblage de composés chimiques, y compris d'agents pharmaceutiques, de plomb et de composés médicamenteux et d'autres substances chimiques, à l'aide de cellules souches embryonnaires humaines (hESC) ou de cellules spécifiques d'une lignée produites à partir de celles-ci. Les méthodes de l'invention sont utiles pour tester la toxicité, en particulier la toxicité au développement, et pour détecter les effets tératogènes de ces composés chimiques.

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