C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2309756
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS274 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS274-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS274 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
L'invention concerne un ensemble de séquences contiguës et partiellement superposées d'ADNc et les polypeptides codés par ces séquences, désignés par BS274 et transcrits à partir du tissu mammaire. Ces séquences sont utiles pour la détection, le diagnostic, la détermination du stade, le surveillance, l'établissement de pronostics, la production d'images in vivo, la prévention ou le traitement, ou la détermination de la prédisposition d'un individu à des pathologies et des troubles mammaires tels que le cancer du sein. L'invention concerne également des anticorps qui se lient spécifiquement aux polypeptides ou protéines codées par BS274, ou des agonistes ou inhibiteurs qui bloquent l'action du polypeptide BS274 spécifique du tissu, ces molécules étant utiles pour le traitement thérapeutique des pathologies, tumeurs ou métastases mammaires.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Friedman Paula N.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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