C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/12 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2303404
Sequences useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer, are described. These sequences are designated as PS213 sequences herein. Also provided are antibodies which specifically bind to PS213-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS213 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
L'invention concerne des séquences utiles pour la détection, le diagnostic, la détermination du stade, la surveillance, le pronostic, la visualisation in vivo, la prévention ou le traitement, ou pour la détermination de la prédisposition d'un individu à des maladies et pathologies de la prostate telles que le cancer de la prostate. Ces séquences sont désignées ici par séquences PS213. L'invention concerne également des anticorps qui se lient spécifiquement au polypeptide ou à la protéine codée par PS213, et des agonistes ou inhibiteurs qui inhibent l'action du polypeptide PS213 spécifique au tissu. Ces molécules sont utiles pour le traitement thérapeutique des maladies, tumeurs ou métastases de la prostate.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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