C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2285039
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS141 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS141-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS141 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
L'invention concerne un ensemble de séquences d'ADNc contiguës et se chevauchant partiellement et de polypeptides codés par ces séquences appelées CS141 et transcrites à partir du tissu gastro-intestinal. Ces séquences sont utiles dans la détection, le diagnostic, la stadification, le contrôle, le pronostic, la prévention ou le traitement, ou la détermination de la prédisposition d'un individu à ces maladies et troubles du tractus gastro-intestinal tels que le cancer. L'invention concerne également des anticorps qui se lient spécifiquement au polypeptide ou à la protéine codé par CS141, et des anticorps ou inhibiteurs qui empêche l'action du polypeptide CS141 spécifique d'un tissu, ces molécules étant utilisées dans la thérapie des maladies du tractus gastro-intestinal, des tumeurs ou métastases.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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